Influence of parenchymal heterogeneity on airway-parenchymal interdependence
نویسندگان
چکیده
منابع مشابه
Airway-parenchymal interdependence after airway contraction in rat lung explants.
The constriction of pulmonary airways is limited by the tethering effect exerted by parenchymal attachments. To characterize this tethering effect at the scale of intraparenchymal airways, we studied the pattern of parenchymal distortion due to bronchoconstriction in a rat lung explant system. First, we measured the elastic modulus under tension for 2% (wt/vol) agarose alone (37.6 +/- 1.5 kPa) ...
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The outward tethering forces exerted by the lung parenchyma on the airways embedded within it are potent modulators of the ability of the airway smooth muscle to shorten. Much of our understanding of these tethering forces is based on treating the parenchyma as an elastic continuum; yet, on a small enough scale, the lung parenchyma in two dimensions would seem to be more appropriately described...
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The topic of airway-parenchymal interdependence (API) is of great importance to those interested in identifying factors that influence airway patency. A carefully designed experiment has raised questions about the classical concept of API. This paper proposes a new mechanism of API. The pulmonary lobe is an aggregated body consisting of many Miller’s lobular polyhedrons and a fractal bronchial ...
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We do not yet have a good quantitative understanding of how the force-velocity properties of airway smooth muscle interact with the opposing loads of parenchymal tethering and airway wall stiffness to produce the dynamics of bronchoconstriction. We therefore developed a two-dimensional computational model of a dynamically narrowing airway embedded in uniformly elastic lung parenchyma and compar...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2013
ISSN: 1569-9048
DOI: 10.1016/j.resp.2013.06.005